Jane A. Cauley, DrPH

Department of Epidemiology
Cancer Epidemiology and Prevention Program (CEPP)

A510 Crabtree Hall
University of Pittsburgh
Pittsburgh, PA 15261
Voice: 412-624-0218
E-mail: JCauley@edc.pitt.edu

Dr. Cauley is Professor and Vice Chair for Research, Department of Epidemiology, University of Pittsburgh (Pennsylvania) Graduate School of Public Health (GSPH).

Her primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in menopause and the multiple physiological, social, pathological changes that occur during this time. Her research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. Her work has focused on use of hormone therapy, osteoporosis, risk of hip fractures and bone density in midlife women to older women.

Dr. Cauley has been involved in women's health for over 25 years. She is the Principal Investigator (PI) of several large cohort studies including the Study of Osteoporotic Fracture (SOF) and the Osteoporotic Fracture Risk in Older Men (MrOS). Results from both of these studies have made major improvements in our understanding of osteoporosis in older men and women. Dr. Cauley was Co-PI for the Women's Health Initiative (WHI) and served as study wide Chair of the Osteoporosis, Calcium and Vitamin D Committee for almost the entire duration of the trial. She is a Co-investigator for the Study of Women's Health Across the Nation (SWAN) with particular emphases on skeletal health and physical function and body composition changes as women transition from midlife to elder status. She is PI of a SWAN ancillary study examining novel measures of hip strength.

Research Interests
  • Epidemiology of Osteoporotic Fractures and Falls
  • Epidemiology of Aging, including Women's health issues, and heart disease
  • Epidemiology of Sex Hormones and Their Relationship to Chronic Disease
  • Epidemiology of Breast Cancer
  • Inflammation, Vitamin D and Fractures/ Osteoporosis
  • Ethnic/Racial Differences in Fracture

Research Support
    Principal Investigator

    • Study of Osteoporotic Fractures (SOF) (1986- present) NIH
    • Osteoporotic Fractures In Men, (MrOS) (1999- present) NIH
    • National Children's Study(2007-12) NICHD
    • Outcomes of Sleep Disorders in Older Men (MrOS Sleep) (2003-present) NHLBI
    • Hip Strength Across the Menopausal Transition (SWAN Hip) (2007-12) NIA
    • Pitt-MCRC for Rheumatic and Musculoskeletal Diseases (2007-12) NIAMS
    • Testosterone Trial (T Trial) (2009-15) University of Pennsylvania/NIA
    • Testosterone Trial CV Sub-set (2011-14) University of Pennsylvania/NIA

    Co-Principal Investigator

    • Study of Women's Health Across the Nation (SWAN) (2004-14) NIAMS

Education & Training
  • Boston College - BSN Nursing, 1975
  • University of Pittsburgh - MPH Epidemiology/Public Health Nursing, 1980
  • University of Pittsburgh - DrPH. Epidemiology, 1983

Selected Publications

Shea MK, Houston DK, Tooze JA, Davis CC, Johnson MA, Hausman DB, Cauley JA, Bauer DC, Tylavsky F, Harris TB, Kritchevsky SB; Health, Aging and Body Composition Study. Correlates and prevalence of insufficient 25-hydroxyvitamin D status in black and white older adults: the health, aging and body composition study. J Am Geriatr Soc. 2011 Jul;59(7):1165-74. PMID: PMC3282467.

Cauley JA. Defining ethnic and racial differences in osteoporosis and fragility fractures. Clin Orthop Relat Res. 2011 Jul;469(7):1891-9. Review. PMID: PMC3111798.

Miljkovic I, Cauley JA, Dressen AS, Gordon CL, Goodpaster BH, Kuller LH, Bunker CH, Patrick AL, Wheeler VW, Orwoll ES, Zmuda JM. Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men. Metabolism. 2011 Aug;60(8):1178-85. PMID: PMC3106138.

Donaldson MG, Cawthon PM, Schousboe JT, Ensrud KE, Lui LY, Cauley JA, Hillier TA, Taylor BC, Hochberg MC, Bauer DC, Cummings SR; Study of Osteoporotic Fractures (SOF). Novel methods to evaluate fracture risk models. J Bone Miner Res. 2011 Aug;26(8):1767-73. PMID:21351143.

Hillier TA, Cauley JA, Rizzo JH, Pedula KL, Ensrud KE, Bauer DC, Lui LY, Vesco KK, Black DM, Donaldson MG, Leblanc ES, Cummings SR. WHO absolute fracture risk models (FRAX): do clinical risk factors improve fracture prediction in older women without osteoporosis? J Bone Miner Res. 2011 Aug;26(8):1774-82. PMID:21351144.

Everson-Rose SA, Paudel M, Taylor BC, Dam T, Cawthon PM, Leblanc E, Strotmeyer ES, Cauley JA, Stefanick ML, Barrett-Connor E, Ensrud KE; Osteoporotic Fractures in Men Research Group. Metabolic syndrome and physical performance in elderly men: the osteoporotic fractures in men study. J Am Geriatr Soc. 2011 Aug;59(8):1376-84. PMID:21806561.

Crandall CJ, Cauley JA. ACP Journal Club. Calcium plus vitamin D was associated with increased cardiovascular risk in women not taking personal calcium supplements. Ann Intern Med. 2011 Aug 16;155(4):JC2-3. PMID:21844536.

Barbour KE, Zmuda JM, Horwitz M, Evans R, Strotmeyer ES, Boudreau R, Cauley JA. The association of serum 25-hydroxyvitamin D with indicators of bone quality in men of Caucasian and African Ancestry men. Osteoporos Int 2010; Sep;22(9):2475-85. PMID: 21104232.*

Chen Z, Qi L, Beck T, Robbins J, Wu G, Lewis CE, Cauley JA, Wright NC, Seldin MF. Stronger bone correlates with African admixture in African American women. J Bone Miner Res. 2011 2011 Sep;26(9):2307-16. PMID:21590740.

Cauley JA, Danielson ME, Boudreau R, Barbour KE, Horwitz MJ, Bauer DC, Ensrud KE, Manson JE, Wactawski-Wende J, Shikany JM, Jackson RD. Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: The women's health initiative (WHI). J Bone Miner Res. 2011 Oct;26(10):2378-88. NIHMS305356.

Yaffe K, Lindquist K, Schwartz AV, Vitartas C, Vittinghoff E, Satterfield S, Simonsick EM, Launer L, Rosano C, Cauley JA, Harris T. Advanced glycation end product level, diabetes, and accelerated cognitive aging. Neurology. 2011 Oct 4;77(14):1351-6. PMID: PMC3182758.

Martin E, Haney E, Shannon J, Cauley J, Ensrud K, Zmuda J, Orwoll E, Marshall L. Femoral volumetric bone density and dimensions in relation to serum 25-hydroxy vitamin D levels among elderly men. J Bone Miner Res 2011; 26 (Suppl 1), S480.

Leblanc ES, Hillier TA, Pedula KL, Rizzo JH, Cawthon PM, Fink HA, Cauley JA, Bauer DC, Black DM, Cummings SR, Browner WS. Hip Fracture and Increased Short-term but Not Long-term Mortality in Healthy Older Women. Arch Intern Med. 2011;171(20):1831-7. PMID:21949033.

Leblanc ES, Wang PY, Lee CG, Barrett-Connor E, Cauley JA, Hoffman AR, Laughlin GA, Marshall LM, Orwoll ES. Higher Testosterone Levels Are Associated with Less Loss of Lean Body Mass in Older Men. J Clin Endocrinol Metab. J Clin Endocrinol Metab. 2011 Dec;96(12):3855-63. PMID: PMC3232620.

Tranah G, Stone K, Yaffe K, Ancoli Israel S, Redline S, Cauley JA, Ensrud K, Paudel M, Hillier, Blackwell T, Cummings S. Circadian activity rhythms and risk of incident dementia and MCI in older women. In press, Annals of Neurology, 2011 Nov;70(5):722-32. PMID: PMC3244839.

Hillier TA, Lui LY, Kado DM, Leblanc E, Vesco KK, Bauer DC, Cauley JA, Ensrud KE, Black DM, Hochberg MC, Cummings SR. Height loss in older women: Risk of hip fracture and mortality independent of vertebral fractures. J Bone Miner Res. 2011 Nov 9. [Epub ahead of print]. PMID:22072593.

Simon MS, Rosenberg CA, Rodabough RJ, Greenland P, Ockene I, Roy HK, Lane DS, Cauley JA, Khandekar J. Prospective Analysis of Association Between Use of Statins or Other Lipid-Lowering Agents and Colorectal Cancer Risk. Ann Epidemiol. 2012 Jan;22(1):17-27. PMID:22056480.

Ishii S, Cauley JA, Crandall CJ, Srikanthan P, Greendale GA, Huang MH, Danielson ME, Karlamangla AS. Diabetes and Femoral Neck Strength: Findings from The Hip Strength Across the Menopausal Transition Study. J Clin Endocrinol Metab. 2012 Jan;97(1):190-7. PMID:22072739.

Gourlay ML, Fine JP, Preisser JS, May RC, Li C, Lui LY,. Ransohoff DF, Cauley JA, Ensrud KE for the Study of Osteoporotic Fractures Research Group. Bone mineral density testing interval and transition to osteoporosis in older postmenopausal women. N Engl J Med. 2012 Jan 19;366(3):225-33. PMID: NIHMS356906.

Wright NC, Lisse JR, Beck TJ, Sherrill DL, Mohler MJ, Bassford T, Cauley JA, Lacroix AZ, Lewis CE, Chen Z. Rheumatoid Arthritis is Associated With Less Optimal Hip Structural Geometry. J Clin Densitom. 2012 Jan-Mar;15(1):39-48. PMID: NIHMS305876.

Woodard GA, Narla VV, Ye R, Cauley JA, Thompson T, Matthews KA, Sutton-Tyrrell K. Racial differences in the association between carotid plaque and aortic and coronary artery calcification among women transitioning through menopause. Menopause. 2012 Feb;19(2):157-63. PMID: NIHMS309023.

Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, Cauley JA, Cosman F, Cummings SR, Hue TF, Lippuner K, Lakatos P, Leung PC, Man Z, Martinez R, Tan M, Ruzycky ME, Su G, Eastell R. The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res. 2012 Feb;27(2):243-54. PMID: 22161728.

Crandall CJ, Aragaki AK, Cauley JA, McTiernan A, Manson JE, Anderson G, Chlebowski RT. Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women's health initiative clinical trials. Breast Cancer Res Treat. 2012 Feb;132(1):275-85. PMID:22042371.

Crandall CJ, Aragaki AK, Cauley JA, McTiernan A, Manson JE, Anderson GL, Wactawski-Wende J, Chlebowski RT. Breast tenderness after initiation of conjugated equine estrogens and mammographic density change. Breast Cancer Res Treat. 2012 Feb;131(3):969-79. PMID:21979747.

Katzman W, Cawthon P, Hicks GE, Vittinghoff E, Shepherd J, Cauley JA, Harris T, Simonsick EM, Strotmeyer E, Womack C, Kado DM. Association of Spinal Muscle Composition and Prevalence of Hyperkyphosis in Healthy Community-Dwelling Older Men and Women. J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):191-5.PMID: PMC3297013.

Diem SJ, Harrison SL, Haney E, Cauley JA, Stone KL, Orwoll E, Ensrud KE; for the Osteoporotic Fractures in Men (MrOS) Research Group. Depressive symptoms and rates of bone loss at the hip in older men. Osteoporos Int. 2012 Mar 30. PMID:22461074. [Epub ahead of print].

Bow CH, Cheung E, Cheung CL, Xiao SM, Loong C, Soong C, Tan KC, Luckey MM, Cauley JA, Fujiwara S, Kung AW. Ethnic difference of clinical vertebral fracture risk. Osteoporos Int. 2012 Mar;23(3):879-85. PMID: PMC3277693. Epub 2011 Apr 2.

Arasu A, Cawthon PM, Lui LY, Do TP, Arora PS, Cauley JA, Ensrud KE, Cummings SR; The Study of Osteoporotic Fractures Research Group. Serum Sclerostin and Risk of Hip Fracture in Older Caucasian Women. J Clin Endocrinol Metab. 2012 Mar 30. PMID:22466341 [Epub ahead of print].

Curtis JR, Ewing SK, Bauer DC, Cauley JA, Cawthon PM, Barrett-Connor E, Haney EM, Ishani A, Cremers S, Orwoll E. Association of Intact Parathyroid Hormone Levels with Subsequent Hip BMD Loss: The Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab. 2012 Mar 22. PMID:22442276 [Epub ahead of print]

Boonen S, Eastell R, Su G, Mesenbrink P, Cosman F, Cauley JA, Reid IR, Claessens F, Vanderschueren D, Lyles KW, Black DM. Time-to-onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis. J Bone Miner Res. 2012 Mar 19. PMID:22431413 [Epub ahead of print].

Ensrud KE, Barbour K, Canales MT, Danielson ME, Boudreau RM, Bauer DC, Lacroix AZ, Ishani A, Jackson RD, Robbins JA, Cauley JA. Renal function and nonvertebral fracture risk in multiethnic women: the Women's Health Initiative (WHI). Osteoporos Int. 2012 Mar;23(3):887-99. PMID:21625880.

Ishii S, Cauley JA, Greendale GA, Danielson ME, Safaei Nili N, Karlamangla A. Ethnic differences in composite indices of femoral neck strength. Osteoporos Int. 2011 2012 Apr;23(4):1381-90. Erratum in: Osteoporos Int. 2012 Apr;23(4):1391-2. PMID:21927926.

Napoli N, Jin J, Peters K, Wustrack R, Burch S, Chau A, Cauley J, Ensrud K, Kelly M, Black DM. Are Women with Thicker Cortices in the Femoral Shaft at Higher Risk of Subtrochanteric/ Diaphyseal Fractures? The Study of Osteoporotic Fractures. J Clin Endocrinol Metab. 2012 Apr 30. PMID:22547423. [Epub ahead of print]

Yenchek RH, Ix JH, Shlipak MG, Bauer DC, Rianon NJ, Kritchevsky SB, Harris TB, Newman AB, Cauley JA, Fried LF; for the Health, Aging, and Body Composition Study. Bone Mineral Density and Fracture Risk in Older Individuals with CKD. Clin J Am Soc Nephrol. 2012 Apr 19. PMID:22516286 [Epub ahead of print].

Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Cauley JA et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012 Apr 15;44(5):491-501. PMID:PMC3338864.

Metti AL, Cauley JA, Newman AB, Ayonayon HN, Barry LC, Kuller LM, Satterfield S, Simonsick EM, Yaffe K. Plasma Beta Amyloid Level and Depression in Older Adults. J Gerontol A Biol Sci Med Sci. 2012 Apr 12. PMID: 22499763. [Epub ahead of print] *

Gourlay ML, Preisser JS, Lui LY, Cauley JA, Ensrud KE; the Study of Osteoporotic Fractures Research Group. BMD screening in older women: Initial measurement and testing interval. J Bone Miner Res. 2012 Apr;27(4):743-6. PMID:22392569.

Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, Weissfeld JL, Wolmark N. Body Mass Index and the Risk for Developing Invasive Breast Cancer among High-Risk Women in NSABP P-1 and STAR Breast Cancer Prevention Trials. Cancer Prev Res (Phila). 2012 Apr;5(4):583-92. PMID:NIHMS356488. *

Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, Lacroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA. Inflammatory markers and the risk of hip fracture: The women's health initiative. J Bone Miner Res. 2012 May;27(5):1167-1176. PMID:22392817. *

Houston DK, Neiberg RH, Tooze JA, Hausman DB, Johnson MA, Cauley JA, Bauer DC, Shea MK, Schwartz GG, Williamson JD, Harris TB, Kritchevsky SB; for the Health ABC Study. Low 25-Hydroxyvitamin D Predicts the Onset of Mobility Limitation and Disability in Community-Dwelling Older Adults: The Health ABC Study. J Gerontol A Biol Sci Med Sci. 2012 May 9. PMID:22573914. [Epub ahead of print].

Barbour KE, Houston DK, Cummings SR, Boudreau R, Prasad T, Sheu Y, Bauer DC, Tooze JA, Kritchevsky SB, Tylavsky FA, Harris TB, Cauley JA; the Health ABC study. Calciotropic hormones and the risk of hip and non-spine fractures in older adults: The Health ABC study. J Bone Miner Res. 2012 May;27(5):1177-1185.PMID: 22228250. *

Vesco KK, Marshall LM, Nelson HD, Humphrey L, Rizzo J, Pedula KL, Cauley JA, Ensrud KE, Hochberg MC, Antoniucci D, Hillier TA; for the Study of Osteoporotic Fractures. Surgical menopause and nonvertebral fracture risk among older US women. Menopause. 2012 May;19(5):510-516. PMID: PMC3342015.

Barbour KE, Zmuda JM, Boudreau R, Strotmeyer ES, Horwitz MJ, Evans RW, Kanaya AM, Harris TB, Cauley JA; The Health ABC Study. The effects of adiponectin and leptin on changes in bone mineral density. Osteoporos Int. 2012 Jun;23(6):1699-1710. PMID:21877199. *