Jian-Min Yuan, M.D., PhD

Arnold Palmer Endowed Chair in Cancer Prevention
Professor, Department of Epidemiology, Graduate School of Public Health
Associate Director for Cancer Prevention and Population Sciences
Leader for the Cancer Epidemiology and Prevention Program (CEPP)
University of Pittsburgh Cancer Institute
University of Pittsburgh Medical Center (Shadyside) Cancer Pavilion
5150 Centre Avenue - Suite 4C
Pittsburgh, PA 15232
Phone: 412-864-7889
Fax: 412-864-7838
E-mail: yuanj@upmc.edu

Brooke Curry Spencer
Office Administrator
Cancer Epidemiology and Prevention Program (CEPP)
University of Pittsburgh Cancer Institute
University of Pittsburgh Medical Center (Shadyside) Cancer Pavilion
5150 Centre Avenue - Suite 4C
Pittsburgh, PA 15232
Phone: 412-864-7861
Fax: 412-864-7838
email: spencerbd@upmc.edu


Research Interests
  • Environmental exposure and gene-environmental interaction in the etiology of cancer
  • Biomarkers in relation to the development of cancer and risk prediction of cancer
  • Chemopreventive effect of dietary agents for primary prevention of cancer
  • Health outcomes and prognosis of cancer patients after behavior changes
Research Support
    Principal Investigator

    • 01/15/2010-12/31/2014
      Prospective Studies of Cancer Etiology and Prevention in Shanghai and Singapore
      National Institutes of Health (NIH)/National Cancer Institute (NCI)


    • 07/01/2009-06/30/2014
      Biomarkers of NNK in Prediction of Lung Cancer Development in Smokers
      National Institutes of Health (NIH)/National Cancer Institute (NCI)


    Co-Principal Investigator (Subaward):

    • 09/23/2011-08/31/2015
      NCI Cohort Consortium for One-Carbon Metabolism and Lung Cancer
      National Institutes of Health (NIH)/National Cancer Institute (NCI)


    • 09/10/1997-07/31/2015
      Cancer Center Support Grant
      National Institutes of Health (NIH)/National Cancer Institute (NCI)
      [Program Leader, Cancer Epidemiology, Prevention & Control Program]
Education & Training
  • Shanghai Medical University - MD, Medicine, 1983
  • Shanghai Medical University - MPH, Public Health/Epidemiology, 1986
  • University of Southern California - PhD, Epidemiology, 1996
Selected Publications

Refereed Articles (2012 - present)

  1. Yuan J-M, Gao Y-T, Wang R, Chen M, Carmella SG, Hecht SS. Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. Carcinogenesis 33:804-809, 2012. [PMC3384073]

  2. Jiang X, Castelao JE, Yuan J-M, Stern MC, Conti DV, Cortessis VK, Pike MC, Gago-Dominguez M. Cigarette smoking and subtypes of bladder cancer. Int J Cancer. 130(4):896-901, 2012. [PMC3210924]

  3. Cash HL, *Tao L, Yuan J-M, Marsit CJ, Houseman EA, Xiang Y-B, Gao Y-T, Nelson HN, Kelsey KT. LINE-1 hypomethylation is associated with bladder cancer risk among non-smoking Chinese. Int J Cancer. 130(5):1151-9, 2012. [PMC3208798]

  4. *Tao L, Xiang Y-B, Chan KK, Wang R, Gao Y-T, Yu MC, Yuan J-M. Cytochrome P4501A2 phenotype and bladder cancer risk: the Shanghai Bladder Cancer Study. Int J Cancer. 130(5):1174-83, 2012. [PMC3167995]

  5. Lee E, Hsu C, Van den Berg D, Ursin G, Koh WP, Yuan J-M, Stram DO, Yu MC, Wu AH. Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev 21(4):635-644, 2012. [PMC3408217]

  6. Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, Li XM, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Liao LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Chung CC, Wang C, Wheeler W, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Zhao XK, Li JM, Li AL, Sun LD, Wei W, Li JL, Zhang P, Li HL, Cui WY, Wang WP, Liu ZC, Yang X, Fu WJ, Cui JL, Lin HL, Zhu WL, Liu M, Chen X, Chen J, Guo L, Han JJ, Zhou SL, Huang J, Wu Y, Yuan C, Huang J, Ji AF, Kul JW, Fan ZM, Wang JP, Zhang DY, Zhang LQ, Zhang W, Chen YF, Ren JL, Li XM, Dong JC, Xing GL, Guo ZG, Yang JX, Mao YM, Yuan Y, Guo ET, Zhang W, Hou ZC, Liu J, Li Y, Tang S, Chang J, Peng XQ, Han M, Yin WL, Liu YL, Hu YL, Liu Y, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Liu HL, Yuan L, Jin Y, Zhang YR, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Zhang GF, Yue WB, Feng CW, Qige Q, Zhao JT, Yang WJ, Lei GY, Chen LQ, Li EM, Xu LY, Wu ZY, Bao ZQ, Chen JL, Li XC, Zhuang X, Zhou YF, Zuo XB, Dong ZM, Wang LW, Fan XP, Wang J, Zhou Q, Ma GS, Zhang QX, Liu H, Jian XY, Lian SY, Wang JS, Chang FB, Lu CD, Miao JJ, Chen ZG, Wang R, Guo M, Fan ZL, Tao P, Liu TJ, Wei JC, Kong QP, Fan L, Wang XZ, Gao FS, Wang TY, Xie D, Wang L, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Goldstein AM, Yuan ZQ, Chanock SJ, Zhang XJ, Taylor PR, Wang LD. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: A meta-analysis of genome-wide association studies. Hum Mol Genet. 21(9):2132-41, 2012. [PMC3315211]

  7. Naidoo N, Van Dam RM, Koh W-P, Chen C, Lee YP, Yuan J-M, Ong C-N. Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults. J Nutr. 142(6):1046-52, 2012. [PMC3349975]

  8. Lim V, Li J, Gong Y, Yuan J-M, Wu TS, Hammond J, Jin A, Koh W-P, Yong EL. Serum free estradiol and estrogen receptor-? mediated estrogenic activity are related to decreased incident hip fractures in older women. Bone. 50(6):1311-6, 2012. [PMC3353105]

  9. Thyagarajan B, Wang R, Barcelo H, Koh W-P, Yuan J-M. Mitochondrial copy number is associated with colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. Sep;21(9):1574-81, 2012. [PMC3437007]

  10. *Inoue-Choi M, Nelson HH, Robien K, Arning E, Bottiglieri T, Koh WP, Yuan J-M. One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. Intl J Mol Epidemiol Genet. 3(2):160-173, 2012. [PMC3376917]

  11. Robien K, Butler LM, Wang R, Koh W-P, Yuan J-M. Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore. Br J Nutr 15:1-10, 2012. [PMC3442149]

  12. Odegaard AO, Koh WP, Yuan J-M, Gross MD, Pereira MA. Western-style fast food intake and cardiometabolic risk in an Eastern country. Circulation. Jul 10;126(20): 182-8, 2012. [PubMed - indexed for MEDLINE]

  13. Hecht SS, Murphy SE, Stepanov I, Nelson HH, Yuan J-M. Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai Cohort Study. Cancer Lett. Jul 20 2012. [Epub ahead of print]; [PMC3648613]

  14. Mueller N, Odegaard A, Gross MD, Koh WP, Yuan J-M, Pereira MA, Age at menarche and cardiovascular disease mortality in Chinese women: The Singapore Chinese Health Study. Am J Epidemiol. Oct;22(10):717-22, 2012. [PMC3459135]

  15. Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, Hutchinson A, Deng X, Liu C, Horner MJ, Cullen M, Epstein CG, Burdett L, Dean MC, Chatterjee N, Sampson J, Chung CC, Kovaks J, Gapstur SM, Stevens VL, Teras LT, Gaudet MM, Albanes D, Weinstein SJ, Virtamo J, Taylor PR, Freedman ND, Abnet CC, Goldstein AM, Hu N, Yu K, Yuan J-M, Liao L, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Aldrich MC, Amos C, Blot WJ, Bock CH, Gillanders EM, Harris CC, Haiman CA, Henderson BE, Kolonel LN, Le Marchand L, McNeill LH, Rybicki BA, Schwartz AG, Signorello LB, Spitz MR, Wiencke JK, Wrensch M, Wu X, Zanetti KA, Ziegler RG, Figueroa JD, Garcia-Closas M, Malats N, Marenne G, Prokunina-Olsson L, Baris D, Schwenn M, Johnson A, Landi MT, Goldin L, Consonni D, Bertazzi PA, Rotunno M, Rajaraman P, Andersson U, Beane Freeman LE, Berg CD, Buring JE, Butler MA, Carreon T, Feychting M, Ahlbom A, Gaziano JM, Giles GG, Hallmans G, Hankinson SE, Hartge P, Henriksson R, Inskip PD, Johansen C, Landgren A, McKean-Cowdin R, Michaud DS, Melin BS, Peters U, Ruder AM, Sesso HD, Severi G, Shu XO, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Silverman DT, Kogevinas M, Gonzalez JR, Villa O, Li D, Duell EJ, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Hassan M, Wheeler W, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross MD, Holly EA, Klein AP, LaCroix A, Mandelson MT, Petersen G, Boutron-Ruault MC, Bracci PM, Canzian F, Chang K, Cotterchio M, Giovannucci EL, Goggins M, Hoffman Bolton JA, Jenab M, Khaw KT, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Rabe KG, Riboli E, Tjonneland A, Tobias GS, Trichopoulos D, Elena JW, Yu H, Amundadottir L, Stolzenberg-Solomon RZ, Kraft P, Schumacher F, Stram D, Savage SA, Mirabello L, Andrulis IL, Wunder JS, Patino Garcia A, Sierrasesumaga L, Barkauskas DA, Gorlick RG, Purdue M, Chow WH, Moore LE, Schwartz KL, Davis FG, Hsing AW, Berndt SI, Black A, Wentzensen N, Brinton LA, Lissowska J, Peplonska B, McGlynn KA, Cook MB, Graubard BI, Kratz CP, Greene MH, Erickson RL, Hunter DJ, Thomas G, Hoover RN, Real FX, Fraumeni JF, Jr., Caporaso NE, Tucker M, Rothman N, Perez-Jurado LA, Chanock SJ. Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet 44:651-658, 2012. [PMC3372921]

  16. Montague JA, Butler LM, Wu AH, Genkinger JM, Koh W-P, Wong AS, Wang R, Yuan J-M, Yu MC. Green and black tea intake in relation to prostate cancer risk among Singapore Chinese. Cancer Causes Control. Oct; 23(10):1635-41, 2012 [PMC3695613]

  17. Koh GC, Tai BC, Ang L-W, Heng D, Yuan J-M, Koh W-P. All-cause and cause specific mortality after hip fracture among Chinese women and men: The Singapore Chinese Health Study. Osteoporosis Intl. Jul;24(7):1981-9, 2013 [PubMed - indexed for MEDLINE]

  18. Dai Z, Wang R, Ang LW, Yuan J-M, Koh WP. Dietary B vitamin intake and risk of hip fracture: The Singapore Chinese Health Study. Osteoporosis Int. Jul;24(7):2049-59, 2013 [PubMed indexed for MEDLINE]

  19. Birmann BM, Neuhouser ML, Rosner B, Albanes D, Buring JE, Giles GG, Lan Q, Lee I-M, Purdue MP, Rothman N, Severi G, Yuan J-M, Anderson KC, Pollak M, Rifai N, Hartge P, Landgren O, Lessin L, Virtamo J, Wallace RB, Manson JE, Colditz GA. Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium. Blood. Dec 13; 120(25):4929-37, 2012 [PMC3525019]

  20. Thean LF, Li HH, Teo YY, Koh W-P, Yuan J-M, Teoh ML, Koh WP, Tang CL, Cheah PY. (2012) Association of Caucasian-Identified Variants with Colorectal Cancer Risk in Singapore Chinese. PLoS ONE 7(8): e42407, 2012 [PMC3411754]

  21. Xiong M, Nguyen R, Strayer L, Chanthanouvong S, Yuan J-M. Knowledge and behaviors toward Hepatitis B and the Hepatitis B vaccine in the Laotian community in Minnesota. J Immig Min Health. 15(4):771-778, 2013 [PMC3951138]

  22. Li J, Koh WP, Jin AZ, Yuan J-M, Yu MC, Butler LM. Calcium intake is not related to breast cancer risk among Singapore Chinese women. Int J Cancer. Aug 1;133(3):690-6, 2013 [PMC372733]

  23. Lee E, Van Den Berg D, Hsu C, Ursin G, Koh WP, Yuan J-M, Stram DO, Yu MC, Wu A. Genetic variation in Transforming Growth Factor beta 1 and mammographic density in Singapore Chinese women. Cancer Res 73:1876-82 [PMC3740538]

  24. Mueller NT, Koh WP, Odegaard AO, Gross MD, Yuan J-M, Pereira MA. Asthma and the risk of type 2 diabetes in the Singapore Chinese Health Study. Diabetes Res Clin Pract. Feb;(99)2:192-9. [PMC3615124]

  25. Wu A, Stanczyk FZ, Wang R, Koh W-P, Yuan J-M, Yu M. Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore. Int J Cancer 132(4):891-6, 2013 Feb 15 [PMC3477268]

  26. Yuan J-M, Fan Y, Ognjanovic S, Wang R, Van Den Berg D, Govindarajan S, Yu MC. Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: Two case-control studies. BMC Gastroenterol. Feb 18;13:32, 2013 [PMC3621500]

  27. Teng GG, Tan CS, Santosa A, Saag KG, Yuan J-M, Koh W-P. Serum urate levels and consumption of common beverages and alcohol among Chinese in Singapore. Arthritis Care Res (Hoboken). Mar 5 2013 [Epub ahead of print] [PMC3710722]

  28. Koh WP, Wang R, Jin A, Yu MC, Yuan J-M. Diabetes mellitus and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study. Br J Cancer. Mar 19;108(5):1182-8, 2013. [PMC3619062]

  29. Prizment A, Anderson KE, Yuan J-M, Folsom AR. Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study. Cancer Causes Control. Mar; 24(3):603-8, 2013 [PMC3574198]

  30. Odegaard AO, Koh WP, Yuan J-M. Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population. Cancer Prev Res (Phila). Apr;6(4):360-7, 2013 [PMC3618573]

  31. Jin A, Koh W-P, Chow Khuan Yew, Yuan J-M, Jafar TH. Smoking and risk of kidney failure in the Singapore Chinese Health Study. PLoS One. 8(5):e62962, May 2013. [PMC3650019]

  32. Lee E, Su YC, Lewinger JP, Hsu C, Van Den Berg D, Ursin G, Koh W-P, Yuan J-M, Stram DO, Yu M, Wu AH. Hormone metabolism genes and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 22(5):984-6 May 2013 [PubMed - in process]

  33. Butler LM, Montague JA, Koh W-P, Wang R, Yu MC, Yuan J-M. Fried meat intake is a risk factor for lung adenocarcinoma in a prospective cohort of Chinese men and women in Singapore. Carcinogenesis. Aug;34(8):1794-9, 2013 [PMC3731803]

  34. Tao L, Day BW, Hu B, Xiang Y-B, Wang R, Stern MC, Gago-Dominguez M, Cortessis VK, Conti DV, Van Den Berg D, Pike MC, Gao Y-T, Yu MC, Yuan J-M. Elevated 4-Aminobiphenyl and 2, 6-Dimethylaniline Hemoglobin Adducts and Increased Risk of Bladder Cancer among Lifelong Nonsmokers - The Shanghai Bladder Cancer Study. Cancer Epidemiol Prev Biomarkers. May;22(5):937-45, 2013 [PubMed - indexed for MEDLINE]

  35. Thyagarajan B, Wang R, Nelson H, Barcelo H, Koh W-P, Yuan J-M. Mitochondrial DNA copy number is associated with breast cancer risk. PLoS ONE. Jun 12;8(6):e65968, 2013 [PMC3680391]

  36. Catsburg CE, Gago-Dominguez M, Yuan JM, Castelao JE, Cortessis VK, Pike MC, Stern MC. Dietary sources of N-nitroso compounds and bladder cancer risk: Findings from the Los Angeles Bladder Cancer Study. Int J Cancer. Jun 18, 2013 [Epub ahead of print] [PubMed - indexed for MEDLINE]

  37. Chen J-G, Egner PA, Ng D, Jacobson LP, Munoz A, Zhu Y-R, Qian G-S, Wu F, Yuan J-M, Groopman JD, Kensler TW. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of china. Cancer Prev Res (Phila) 6:1038-1045, 2013. [PMC3800239]

  38. Wu AH, Stanczyk FZ, Wang R, Koh WP, Yuan J-M, Yu MC. Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore. Int J Cancer 132:891-896, 2013. [PMC3477268]

  39. Clark ML, Butler LM, Koh WP, Wang R, Yuan J-M. Dietary fiber intake modifies the association between secondhand smoke exposure and coronary heart disease mortality among Chinese non-smokers in Singapore. Nutrition 29:1304-1309, 2013. [PubMed - in process]

  40. *Inoue-Choi M, Nelson HH, Robien K, Arning E, Bottiglieri T, Koh W-P, Yuan J-M. Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore. BMC Cancer 13:389, 2013. [PMC3765398]

  41. Dai Z, Wang R, Ang L-W, Low Y-L, Yuan J-M, Koh W-P. Protective effects of dietary carotenoids on risk of hip fracture in men: The Singapore Chinese Health Study. J Bone Miner Res (in press), 2013. [PMC3894263]

  42. Stepanov I, Sebero E, Wang R, Gao Y-T, Hecht SS, Yuan J-M. Tobacco-specific N'-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: Remarkable coherence with rat tumor sites. Int J Cancer 134(10):2278-2283, 2013. [PMC3949147]

  43. Yuan J-M, Butler LM, Gao YT, Murphy SE, Carmella SG, Wang R, Nelson HH, Hecht SS. Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in The Shanghai Cohort Study. Carcinogenesis 35(2):339-45, 2013. [PMC3908750]

  44. Mueller NT, Mueller NJ, Odegaard AO, Gross MD, Koh W-P, Yuan J-M, Pereira MA. Higher Parity is Associated with an Increased Risk of Type-II Diabetes in Chinese Women: The Singapore Chinese Health Study. BJOG 120(12):1483-9. [PubMed - indexed for MEDLINE]

  45. *Tao L, Wang R, Gao Y-T, Yuan J-M. Impact of Post-Diagnosis Smoking on Long-term Survival of Cancer Patients: The Shanghai Cohort Study. Cancer Epidemiol Biomarkers Prev 22(12):2404-11. [PMC3919701] ral R, Lewinger JP, Van Den Berg D, Joshi AD, Yuan J-M, Gago-Dominguez M, Cortessis VK, Pike MC, Conti DV, Thomas DC, Gao Y-T, Xiang Y-B, Zhang W, Su Y-C, Stern MC. Comprehensive analyses of DNA repair pathways, smoking, and bladder cancer risk in Los Angeles and Shanghai. Carcinogenesis 2014 Jan 2 [Epub ahead of print] [PubMed - as supplied by publisher]
*Students or postdoctoral trainees.