EDC Active Studies

The EDC is engaged in the research of many projects, which include Aging, Cardiovascular, Psychiatric, Women’s Health, Infectious Disease, Injury Prevention, Obesity and others.


COAST – Clarifying the Optimal Application of SLT Therapy

Selective laser trabeculoplasty (SLT) has been a treatment option for newly diagnosed open-angle glaucoma or ocular hypertension for nearly 20 years. However, few studies have specifically compared multiple energy levels directly in a head-to-head fashion. The overall goal of the COAST Trial is to identify the optimal application of SLT therapy beginning at the time of diagnosis.  read more »

COOL Prime

COOL Prime Study – Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy

COOL Prime is an observational study that will look at the effects of therapeutic hypothermia (TH) vs normothermia (NT) in infants with mild hypoxic ischemic encephalopathy (HIE). The choice of therapy will be based on each clinical site’s existing practice. read more »


LITES – Linking Investigations in Trauma and Emergency Services

The Linking Investigations in Trauma and Emergency Services (LITES) is a research network of US trauma systems and centers with the capability to conduct prospective, multicenter, injury care and outcomes research of relevance to the Department of Defense (DOD). read more »


MATIC 2 – Massive Transfusion in Children-2

Massive Transfusion in Children-2 (MATIC-2) is a study aiming to improve trauma care in children. To do so, children with serious injuries who need emergent care will get one or more treatments that include blood products (component therapy (CT) and low titer group O whole blood (LTOWB)), and medications (Tranexamic Acid (TXA) or salt water). These treatments are already being given to children across the United States, but doctors aren’t sure which bundle of treatments is best. Many studies look at adults, but we don’t always know how to best treat kids. read more »


MINT – Myocardial Ischemia and Transfusion

MINT is a multicenter randomized clinical trial comparing red blood cell transfusion strategies for patients who have had a myocardial infarction and are anemic. The trial will enroll 3500 hospitalized patients diagnosed with myocardial infarction who are anemic (have blood counts less than 10 g/dL) to receive either a liberal or a restrictive transfusion strategy. read more »


PIVOTAL – Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low weight Infants

Patent ductus arteriosus (PDA) affects more than 24,000 infants each year in the United States. It is the most diagnosed cardiovascular condition in preterm infants. This condition is associated with increased mortality and many other harmful, longer-term outcomes, including chronic lung disease (CLD), intestinal injury, and brain damage. Treatment of this subgroup of infants with PDA via percutaneous catheter-closure may be an opportunity to improve their outcomes moving forward. read more »


POWERS – Physiology of the Weight Reduced State

POWERS will provide a lifestyle intervention with trained clinical staff to help participants lose weight and then study why some people can keep the weight off while others regain their lost weight. Knowledge gained from this important study is intended to help health professionals develop new treatments to improve the maintenance of lost weight. POWERS is a partnership between research universities in the Northeastern U.S., a Data Coordinating Center and NIH. read more »


SCD-CARRE – Sickle Cell Disease and CardiovAscular Risk – Red cell Exchange Trial

The purpose of this study is to carefully evaluate the effects of giving long-term red blood cell exchange transfusion to a group of patients with SCD with certain risk factors for severe organ damage or early death. We want to know if regular exchange blood transfusion will minimize complications in patients with SCD or reduce the chances of new serious problems occurring in patients with sickle cell disease. read more »

SONO Sleep Study

SONO Sleep Study – Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Phenotypes Based on Objective Sleep Duration

The overall goal of the SONO Sleep Study is to determine the effect of insomnia subtype on insomnia remission and secondary outcomes (e.g., symptom severity, sleep efficiency) after treatment with CBT-I and to test the efficacy of trazodone among non-remitters to CBT-I in a placebo-controlled RCT. Our study is will help to change the subtyping of insomnia, its clinical management, and future research. read more »


SWAN – Study of Women’s Health Across the Nation

The Study of Women’s Health Across the Nation (SWAN) is a multi-site longitudinal, epidemiologic study designed to examine the health of women during their middle years. The study examines the physical, biological, psychological and social changes during this transitional period. read more »

Interested in Working with the EDC?

Collaboration with other institutions has always been essential to our work. Please contact us for more information on how working with the EDC can benefit your organization.


M-F, 8:30am to 5pm ET

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Mailing Address

Epidemiology Data Center
University of Pittsburgh
4420 Bayard Street, Suite 600
Pittsburgh, PA 15260


Collaboration with other institutions has always been essential to our work. Please contact us for more information on how working with the EDC can benefit your organization. research@edc.pitt.edu